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Can Depakote Cause Insomnia

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Restless Legs Syndrome And Periodic Leg Movement Disorder

Divalproex Nursing Considerations, Side Effects, and Mechanism of Action Pharmacology for Nurses

Restless Legs Syndrome is a common neurologic condition marked by the urge to move, particularly the legs, which occurs primarily at rest in the evening or bedtime. The essential criteria for making the diagnosis include: 1) The urge to move the legs, usually accompanied or caused by uncomfortable and unpleasant sensations in the legs 2) The urge to move or unpleasant sensations begin or worsen with rest or inactivity 3) The urge to move or unpleasant sensations are partially or totally relieved by movement 4) The urge to move or unpleasant sensations are worse in the evening . Sleep disruptionand complaints of decreased quality of life is present in 3/4 of the patients with the syndrome . A majority of RLS patients will have repetitive periodic limb movements on polysomnogram. The RLS/PLMD has a genetic basis and increases with age so that in the geriatric population over 30% of individuals may meet criteria for the diagnosis. RLS/PLMD is also more common in children with AD/HD, patients in renal failure, individuals with low serum ferritin levels , and in patients taking some medications such including antidepressants, antiemetics and antihistamines .

Depakote Withdrawal Symptoms + How Long They Last

Depakote is a compound that is utilized as an anticonvulsant to help prevent seizures in epileptics. It also has mood stabilizing properties and is approved to help treat and prevent mania among individuals with bipolar disorder. In some cases it is prescribed for the treatment of migraine headaches as well. Other off-label uses for Depakote include: impulse control disorders and spasms.

Most people that use it for the intended purposes of treating epilepsy and/or mania in bipolar disorder find that it works quite well. Despite the fact that the drug can be very effective, the way it works is not well understood. Some hypothesize that it may work on voltage-dependent sodium channels and may increase GABA to prevent both seizures and mania. Studies in animals have lead researchers to believe that this may inhibit the reuptake of the neurotransmitter GABA in the brain.

Although many people take this medication for a period of time, some have a difficult time dealing with side effects. Various side effects include: hair loss, nausea, diarrhea, vomiting, indigestion, and vision problems. Additionally it may lead a person to gain weight and cause memory problems. The potentially debilitating side effects are reasons people typically end up withdrawing from this medication.

Alcohol Depakote And Depakote Er

It may be best to avoid or minimize drinking alcohol while taking Depakote and Depakote ER.

Alcohol can worsen some side effects of Depakote and Depakote ER. These include dizziness, sleepiness, and liver damage. Its important to note that Depakote and Depakote ER have a boxed warning for liver damage.*

If you drink alcohol, talk with your doctor about how much is safe for you to drink while youre taking Depakote or Depakote ER.

* A boxed warning is the most serious warning from the FDA. See Side effects explained below for more information.

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Digestive Side Effects Such As Nausea And Constipation

Digestive side effects are possible with Depakote and Depakote ER. These may include:

  • belly pain

Nausea, vomiting, and diarrhea were some of the more common side effects of Depakote and Depakote ER.

What might help

Contact your doctor if you have digestive side effects while taking Depakote or Depakote ER. They can suggest treatment depending on the symptoms you have. If you have symptoms that bother you or dont go away, your doctor may suggest a different treatment for your condition.

How Do The Side Effects Of The 250

What are the Signs of a Depakote® Overdose? (with pictures)

The side effects of Depakote and Depakote ER are expected to be the same regardless of the dose youre prescribed.

However, in general, your risk of side effects from Depakote may be greater with higher doses of the drug.

If youre concerned about your risk of side effects with your dosage of Depakote or Depakote ER, talk with your doctor.

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How Does Amitriptyline Work

Amitriptyline is a type of medicine called a tricyclic antidepressant . These medications work by increasing certain brain chemicals called neurotransmitters like serotonin and norepinephrine to help improve mood, sleep, pain, and anxiety.

Its not clear exactly how amitriptyline works for sleep, but one of its effects is to block histamine, which may result in drowsiness. This is one reason doctors prescribe amitriptyline as a sleep aid.

How Long Do Depakote Withdrawal Symptoms Last

There is no exact timeline for withdrawal from Depakote that applies to everyone. Your experience when coming off of any drug is going to be unique and largely based on individual circumstances. There have been cases of people withdrawing from this medication and feeling better within a week or two, and there have been other cases of people still experiencing withdrawal effects months after their last pill. In most cases, withdrawal symptoms should start to gradually lessen over a period of weeks to months.

The half life of the drug ranges from 9 to 16 hours, therefore the drug itself will be completely cleared from your system within 2 days. Although the drug will be cleared from your body in a relatively short-order, it doesnt mean that you wont experience any withdrawal following the second day. Depending on how long you took this medication, it may take a relatively lengthy time period for your nervous system to readjust for functioning without the drug.

Additionally this is a drug that is thought to affect neurotransmitters in the brain particularly GABA. It may take some time before your GABA levels to reach normal levels after your withdrawal. During withdrawal do your best to realize that these discontinuation effects are not permanent you will eventually recover to how you were before you used Depakote.

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Interventions For Sleep Disturbance In Bipolar Disorder

Bipolar disorder is a common, severe, and chronic disorder. It is often life-threatening with approximately 1 in 5 individuals completing suicide1. The lifetime prevalence of Bipolar I and II is 1% and 0.5%, respectively2, although more liberal definitions of hypomania identify many more patients with bipolar spectrum disorder. Bipolar disorder type I is defined by the presence of at least one manic or mixed episode. Bipolar II requires at least one hypomanic episode and at least one major depressive episode2. The impact that episodes of mania or depression have on the persons life is enormous. After the onset of the disorder, individuals with bipolar disorder who have been hospitalized spend approximately 20% of their life in episodes3 and approximately 50% of their time unwell4. Not surprisingly, bipolar disorder is ranked as one of the top 10 leading causes of disability worldwide.

How Long Do Depakote Side Effects Last


Most side effects of Depakote are temporary and will go away on their own after the medication is stopped. Since everyone metabolizes medications differently, their bodies will adjust to side effects in their own way. Most common side effects, including nausea and tiredness, will improve after two to four months of taking Depakote.

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What Drugs Interact With Depakote

Effects Of Co-Administered Drugs On Valproate Clearance

Drugs that affect the level of expression of hepatic enzymes, particularly those that elevate levels of glucuronosyltransferases , may increase the clearance of valproate. For example, phenytoin, carbamazepine, and phenobarbital can double the clearance of valproate. Thus, patients on monotherapy will generally have longer half-lives and higher concentrations than patients receiving polytherapy with antiepilepsy drugs.

In contrast, drugs that are inhibitors of cytochrome P450 isozymes, e.g., antidepressants, may be expected to have little effect on valproate clearance because cytochrome P450 microsomal mediated oxidation is a relatively minor secondary metabolic pathway compared to glucuronidation and beta-oxidation.

Because of these changes in valproate clearance, monitoring of valproate and concomitant drug concentrations should be increased whenever enzyme inducing drugs are introduced or withdrawn.

The following list provides information about the potential for an influence of several commonly prescribed medications on valproate pharmacokinetics. The list is not exhaustive nor could it be, since new interactions are continuously being reported.

Drugs For Which A Potentially Important Interaction Has Been Observed


Carbapenem Antibiotics

Estrogen-Containing Hormonal Contraceptives



Drugs For Which Either No Interaction Or A Likely Clinically Unimportant Interaction Has Been Observed


Does Depakote Or Depakote Er Cause Sexual Side Effects

Yes, its possible for Depakote or Depakote ER to cause sexual side effects. These werent reported in clinical trials of Depakote DR tablets, Depakote ER tablets, or Depakote DR sprinkle capsules. However, there have been reports of sexual side effects after the drugs became available for use.

Specifically, erectile dysfunction has been reported with Depakote and Depakote ER. However, it isnt known if Depakote or Depakote ER affects libido .

Tell your doctor if you have sexual side effects while youre taking Depakote and Depakote ER. They may prescribe a different treatment for your condition that doesnt cause these side effects.

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Will I Have Withdrawal Symptoms If I Stop Taking Depakote Or Depakote Er

No, withdrawal symptoms havent been reported with Depakote tablets, ER tablets, or sprinkle capsules. These are side effects that can happen when you stop taking a medication your body is dependent on. Depakote and Depakote ER arent known to cause dependence or withdrawal.

But stopping Depakote or Depakote ER could cause symptoms of your condition to return. For example, if youre taking the drug to help prevent migraine headaches, stopping the medication could cause your migraine headaches to return.

Talk with your doctor if youre interested in stopping Depakote or Depakote ER. They can advise you on how to do it safely. They can also discuss other treatment options for your condition.

Learn more about some of the side effects Depakote and Depakote ER may cause.

Alcohol Use With Depakote And Depakote Er

Depakote (valproic acid)

There is no known interaction between alcohol and Depakote or Depakote ER.

However, your doctor may recommend you avoid alcohol while taking these drugs. This is because alcohol, Depakote, and Depakote ER can cause sleepiness and dizziness on their own. So, drinking alcohol while taking Depakote or Depakote ER may worsen these side effects.

If you drink alcohol, talk with your doctor before taking Depakote or Depakote ER. They can recommend whether how much alcohol, if any, is safe for you to drink while taking the drug.

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Insomnia Associated With Sleep Apnea And Its Treatment

Obstructive sleep apnea induces daytime sleepiness in a significant percentage of affected individuals. Both apnea severity and the level of daytime sleepiness affecting waking function can be negatively affected by the concomitant use of sedatives – particularly opiates and ethanol . In a subset of individuals with OSA, breathing disruption contributes to disordered sleep and insomnia. The treatment of OSA with positive airway pressure can improve sleep quality for such individuals . However for others, PAP therapy can exacerbate insomnia . At altitude and in patients with concomitant heart failure, PAP therapy can induce the development of complex / central apnea – a diagnosis associated with significant complaints of insomnia .

How Should I Take Depakote

  • Take Depakote exactly as your healthcare provider tells you. Your healthcare provider will tell you how much Depakote to take and when to take it.
  • Your healthcare provider may change your dose.
  • Do not change your dose of Depakote without talking to your healthcare provider.
  • Do not stop taking Depakote without first talking to your healthcare provider. Stopping Depakote suddenly can cause serious problems.
  • Swallow Depakote tablets whole. Do not crush or chew Depakote tablets. Tell your healthcare provider if you cannot swallow Depakote whole. You may need a different medicine.
  • If you take too much Depakote call your healthcare provider or local Poison Control Center right away.

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Depakote And Liver Damage

Depakote can cause liver failure. The drug label carries a boxed warning regarding liver failure, or hepatotoxicity.

Hepatoxicity is an inflammation of the liver. It is a serious condition that can be fatal.

There is no treatment, cure or reversal for liver damage. The primary treatment is to discontinue any medications processed through the liver and to avoid alcohol.

Doctors may prescribe medications that help to reduce the symptoms of liver damage. One medication might be a diuretic to reduce fluid accumulation and swelling .

Antipsychotics Can Have Serious Risks

How do you manage insomnia? Can’t Sleep. Life Sucks. Life is meaningless. I want to die. Help

Many people who start taking an antipsychotic drug, stop because of side effects:

  • Dizziness, drowsiness, confusion, and a higher risk of falls and injuries.
  • Weight gain.
  • Muscle twitches, tremors, and spasms. These may not go away even when the drug is stopped.
  • Blood clots. These can lead to serious problems and death if not treated.

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Not Worth The Withdrawal

While taking Xanax to sleep will most likely not have any immediate harmful effects, falling into a pattern of use presents many possible problems. Perhaps most important is that someone regularly taking Xanax can become tolerant to its effects very quickly. Just one to two weeks of nightly Xanax use is enough to build up a tolerance and start requiring more of it to achieve the same insomnia-fighting effects.

As a persons tolerance grows and they need to take more Xanax, they are likely to begin misusing it, and misuse is a short road to abuse, which can then progress to dependence and addiction. Once someone has become dependent on Xanax, especially needing Xanax to sleep, it becomes extremely difficult to stop using. This is in part because the withdrawal symptoms for Xanax, as well as benzodiazepines in general, can be unpleasant, painful, and sometimes even dangerous.

Any attempts to stop using Xanax should be done under the supervision of a medical professional, ideally at a medical detox center. There, generally, an individual will be put on a tapering schedule to slowly lower their Xanax dosage until it is safe for them to stop using.

The worst thing someone can do is try to stop using Xanax all at once. Not only can this bring about difficult to manage symptoms like rebound insomnia, which is typically worse than the initial insomnia someone would have been dealing with before taking Xanax, it can also cause life-threatening seizures.

Can Depakote And Depakote Er Cause Sexual Side Effects In Men And Women

Its possible. Studies have found that valproic acid can affect sex hormones and cause certain sexual side effects. The active drug* in Depakote and Depakote ER, divalproex sodium, is a form of valproic acid.

Sexual side effects of valproic acid can include erectile dysfunction in males and period irregularities in females. Valproic acid can also decrease libido .

If youre concerned about sexual side effects with Depakote or Depakote ER, talk with your doctor. They may be able to recommend treatment for any sexual problems youre having. They may also suggest stopping Depakote or Depakote ER and trying a different medication for your condition.

* The active drug is the ingredient that makes a medication work. Sex and gender exist on spectrums. Use of the terms male and female in this article refers to sex assigned at birth.

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Factors That Influence Depakote Withdrawal

When coming off of any medication, there are various factors that play a role in determining how long the withdrawal process takes as well as the severity of discontinuation symptoms. These factors include things like: the time span over which you took the drug, the dose that you were on, whether you quit cold turkey or tapered, as well as other personal factors.

Antipsychotics Dont Help Much

Depakote (valproic acid)

These drugs are known as atypical antipsychotics. They include aripiprazole , olanzapine , quetiapine , risperidone , and others. The drugs often make people drowsy, but there is little evidence that they actually help you fall or stay asleep. Antipsychotics dont have clear benefits, and the risks can be serious.

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Are There Side Effects From Taking Amitriptyline For Sleep

Amitriptyline can have some serious side effects. Before taking the medicine, be sure to let your doctor know if you have ever had an allergic reaction to amitriptyline or other drugs, or if you have ever had suicidal thoughts or behavior.

Let your doctor know if you have:

  • heart disease, liver, or kidney problems
  • glaucoma, as amitriptyline can increase the pressure in your eye
  • diabetes, as amitriptyline can affect your sugar levels, so you may need to check your sugar more often when you start taking amitriptyline
  • epilepsy, as amitriptyline can increase the risk of seizures

Talk to your doctor if you are pregnant or breastfeeding. Research has not made clear for certain whether amitriptyline is safe to use during pregnancy or if you are breastfeeding.

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