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Does Ranitidine Cause Insomnia

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Dosage Forms Of Ranitidine

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There are different dosage forms of ranitidine , which are shown in Figure 10.61.

Figure 10.61. Dosage forms of ranitidine

The tablet form has different strengths, ranging from 25 mg to 300 mg. There are also 25 mg effervescent tablets that need to be dissolved in water before consumption. One important aspect of ranitidine is its approval as an over-the-counter product since it was previously a prescription-only medicine . After reviewing the overall safety of marketed ranitidine, the US Food and Drug Administration has given it an OTC approval in 75 mg tablets.

Practice questions

Corrado Blandizzi, Carmelo Scarpignato, in, 2011

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I’ve been taking Zantac occasionally for over 20 years even when it was in the prescription only formula. I’ve always found it extremely effective for eliminating in neutralizing stomach acid, it even works great for hangovers. In the past I’ve typically only taking it for one or two days. The Recently I took it for 5 days straight, what a mistake! It caused major constipation, as in no bowel movement for 4 days, even then it was forced with an enema and minimal. My movements have improved over the last 30 hours, though still haven’t returned to normal. I have never been so uncomfortable. So follow directions and dosing, and at the first sign of missing a hotel movement, STOP TAKING IT, it you will regret it.

How Should I Take Ranitidine

Because ranitidine has been withdrawn from the market in the U.S., some of the contents of this leaflet are intended for historical purposes only.

Take ranitidine exactly as directed on the label, or as prescribed by your doctor.

Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device .

It may take up to 8 weeks before your ulcer heals. Keep using your medications as directed and call your doctor if your symptoms do not improve after 6 weeks.

Your doctor may recommend an antacid to help relieve pain. Carefully follow your doctor’s directions about the type of antacid to use, and when to use it.

Store at room temperature away from moisture, heat, and light.

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Table 2 Nonhypnotic Drugs That May Have Excessive Drowsiness As A Side Effect


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Insomnia due to drugs or substances. ICSD-3 defines insomnia as a repeated difficulty in sleep initiation, duration, consolidation, or quality that occurs despite adequate opportunity and circumstances for sleep, and results in some form of daytime impairment. This is a difficult symptom to evaluate. The term “rebound insomnia,” not included in ICSD-3, is used in the literature to describe sleep disturbance characterized by an increase in wakefulness above the previous baseline level after the withdrawal of sedative-hypnotic drugs. It is not synonymous with “withdrawal insomnia,” which implies drug dependence and is usually seen with long-term use of hypnotics. Other hypnotic drugs, such as chloral hydrate, can also lead to withdrawal problems. Withdrawal from sedative or hypnotic drugs is defined as a temporary increase in the severity of insomnia after stopping treatment. If insomnia is worse than it was before the treatment started, the term “recoil” or “overshoot insomnia is used rather than “rebound insomnia.

Patients with preexisting insomnia are at greater risk for developing aggravation of this symptom as an adverse effect of drugs. Drugs and substances associated with insomnia are listed in Table 3, and further details are given under various drugs along with other sleep disorders.

When You Must Not Take It

Zantac 15 mg  free

Do not take STILNOX if you have:

  • been drinking alcohol or you believe that you may have alcohol in your bloodstream
  • sleep apnoea
  • myasthenia gravis
  • severe liver problems
  • acute and/or severe lung problems
  • previously experienced complex sleep behaviours after taking this medicine including sleepwalking, sleep-driving, and/or engaging in other activities while not fully awake.

Do not take STILNOX if you are allergic to it or any of the ingredients listed at the end of this leaflet.

Some symptoms of an allergic reaction include skin rash, itching, shortness of breath or swelling of the face, lips or tongue, which may cause difficulty in swallowing or breathing.

Do not give STILNOX to a child or adolescent. There is no experience with its use in children or adolescents under 18 years of age.

Talk to your doctor or pharmacist if you have ever had a mental disorder or have abused or have been dependent on alcohol or drugs.

Do not take it after the expiry date printed on the pack. If you take it after the expiry date has passed, it may not work as well.

Do not take it if the packaging is damaged or shows signs of tampering.

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Ranitidine May Interact With Other Medications

Ranitidine oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs youre taking. To find out how this drug might interact with something else youre taking, talk to your doctor or pharmacist.

Examples of drugs that can cause interactions with ranitidine are listed below.

Contact A West Virginia Product Liability Lawyer

If you or someone you care about has taken Zantac or a generic version of ranitidine and become ill, please seek legal assistance as soon as possible. At Tiano ODell, PLLC, we are ready to help you through this. Our goal is to investigate what happened and work to secure any compensation you may be entitled to. This could include:

  • Cost of any medical bills
  • Lost income if you cannot work
  • Pain and suffering damages
  • Loss of enjoyment of life damages
  • Possible punitive damages against the manufacturers of these medications

If you need a West Virginia product liability attorney, you can contact us for a free consultation online or by calling 720-6700.

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Zantac And Cancer: Why Is Zantac Still On The Market

The American College of Gastroenterology reports that as many as 60 million Americans suffer from heartburn each month. Considering this fact, it is no wonder that drug manufacturers are cashing in on their discomfort. While people who suffer from heartburn can reduce or eliminate their symptoms through dietary changes and stress management, these methods take time to work.

Valisure, an independent pharmacy, conducted an extensive study of ranitidine in 2019. Their findings illustrated that a single ranitidine tablet contains in excess of 300,000 nanograms of N-Nitrosodimethylamine . To put that in proper context, the acceptable level of NDMA is 96 nanograms per single tablet. Thus, a single dosage of Zantac contained 3000 times the acceptable level of NDMA. Hence, why the Food and Drug Administration pulled all versions of the popular heartburn drugs from shelves on April 1, 2020. The FDA determined that allowing Zantac to remain on the shelves put consumer health and safety at risk.

Dose And Method Of Administration

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Stilnox acts rapidly and should therefore be taken immediately before retiring, or in bed. Stilnox should be taken in a single intake and not be re-administered during the same night. As with all hypnotics, long-term use of zolpidem is not recommended. Treatment should be as short as possible and should not exceed four weeks.For oral use only.

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Warnings For People With Certain Health Conditions

For people with kidney problems: If you have kidney problems or a history of kidney disease, you may not be able to clear this drug from your body well. This may increase the levels of ranitidine in your body and cause more side effects.

For people with liver problems: If you have liver problems or a history of liver disease, you may not be able to process this drug well. This may increase the levels of ranitidine in your body and cause more side effects.

For people with acute porphyria : You shouldnt use this drug if you have a history of an acute porphyria attack. This drug can trigger an acute porphyric attack.

For people with gastric cancer: This drug reduces the amount of acid in your stomach. This can help improve the symptoms of your gastrointestinal condition. However, if your symptoms are caused by a cancerous gastric tumor, you may still have the tumor. This drug does not treat cancer.

Warnings for other groups

For pregnant women: Research in animals has not shown that this drug poses a risk to a pregnancy. However, animal studies do not always predict the way humans would respond. And there arent enough studies of this drug in pregnant humans to see if it is harmful.

That said, this drug should only be used in pregnancy if clearly needed. Call your doctor right away if you become pregnant while taking this drug.

What Should I Do If I Forget A Dose

Triazolam should only be taken at bedtime. If you did not take triazolam at bedtime and you are unable to fall asleep, you may take triazolam if you will be able to remain in bed for 7 to 8 hours afterward. Do not take triazolam if you are not ready to go to sleep right away and stay asleep for at least 7 to 8 hours.

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What Is The Dosage For Ranitidine

Prior to its recall, ranitidine could be taken with or without food.

  • Usual oral doses for treating ulcers and GERD are 150 mg twice daily or 300 mg at bedtime. The maintenance dose is 150 mg daily.
  • Erosive esophagitis is treated with 150 mg 4 times daily.
  • Zollinger-Ellison syndrome may be treated with as much as 6 g daily.
  • Heartburn is treated with 75 mg or 150 mg once or twice daily 30-60 minutes before consuming meals or beverages that cause heartburn.

Self-medication should not last longer than 2 weeks unless advised by a physician.

Histamine Type 2 Receptor Antagonists

Zantac 5 , ranitidine 75 mg dose

H2 antagonists are unlikely significantly to impair CNS function because these compounds do not easily cross the blood-brain barrier, although there is some evidence of CNS penetration. Insomnia and somnolence usually occur in less than 2% of individuals involved in clinical trials. Although such side effects may be infrequent, they are apparently reproducible in susceptible individuals.111 Moreover, the nature of these side effects and the widespread use of H2 antagonists suggest that physicians should be aware of their potential occurrence. Side effects have been most frequently reported with cimetidine, possibly because it has been on the market longer than any of the other compounds. In addition, cimetidine slows the clearance of some benzodiazepines, which may make carryover effects of hypnotics more of a problem. Similarly, cimetidine has been shown to increase levels of theophylline, carbamazepine, and beta-blockers with resultant increases in the CNS effects of these drugs. Ranitidine has produced some of the same effects, although not to the extent seen with cimetidine.112

Paula K. Schweitzer, Angela C. Randazzo, in, 2017

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Table 3 Drugs And Substances Associated With Insomnia




Antidepressants. Sleep disturbances are generally more prevalent among patients with depression. These disturbances may improve with antidepressant treatment, but there may also be adverse effects due to antidepressant drugs. Some antidepressants adversely affect the physiological structure of sleep, whereas others restore it. Most antidepressants cause REM sleep reduction, generally with increased serotonin function. Intense and prolonged dreams often accompany abrupt withdrawal from antidepressant drugs as a manifestation of REM sleep rebound after drug-induced REM sleep deprivation.

Tricyclic antidepressants promote sleep in patients with insomnia due to depression and are likely to cause daytime drowsiness.

Monoamine oxidase inhibitors have also been shown to suppress REM sleep in patients with depression, even eliminating REM sleep in some patients. This class of antidepressants also appears to reduce total sleep time and may decrease sleep efficiency.

Antiemetic drugs. Most antiemetic drugs penetrate the blood-brain barrier and produce sleepiness by their action on the dopaminergic, histaminergic, or cholinergic systems. Hyoscine is a short-acting but powerful anticholinergic agent that reduces REM sleep but increases light sleep. REM sleep is increased on withdrawal of the drug. Domperidone is an exception because it acts on the chemoreceptor trigger zone outside the blood-brain barrier and is unlikely to cause sleepiness.

Before Taking This Medicine

If you have been taking prescription-strength ranitidine: Before you stop taking the medicine, ask your doctor about safer treatment options.

If you have been taking over-the-counter ranitidine: Stop taking the medicine, and ask your doctor or pharmacist about other approved OTC stomach acid reducers.

Heartburn can mimic early symptoms of a heart attack. Get emergency medical help if you have chest pain that spreads to your jaw or shoulder and you feel anxious or light-headed.

Before using any OTC medicine to reduce stomach acid, ask a doctor or pharmacist if the medicine is safe for you if you have other medical conditions or allergies.

Ask a doctor before using any OTC stomach acid medicine if you are pregnant or breastfeeding.

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ranitidine This is excellent. 150mg twice a day, or 300mg at night. Have used off and on for years. Highly reccomend trying it, I cant think of another remedy with fewer side effects, ease of use, or more cost effective. This IS available OTC in 150 and 75mg strengths, the box says 75-150mg but thats for heartburn, it is extremely safe to take 300mg/day or even more. start with 150mg X 2 or 300mg at night.

Potential Side Effects Of Using Zantac

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As with most drugs, side effects are possible and even common. You should speak with your doctor to ensure you understand the potential side effects that may occur when taking Zantac.

The following are common side effects that may arise when taking Zantac:

* Constipation

* Skin or eyes that appear yellow* Dark-colored urine* Infection* Pneumonia symptoms

Additionally, ranitidine can cause a severe allergic reaction in some people, although this reaction is extremely rare. Symptoms of a Zantac allergic reaction include itching or swelling on the face or mouth, difficulty breathing and rash. Call 911 or visit your nearest emergency room as soon as possible if you experience any of these symptoms after taking ranitidine.

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Gynecomastia Impotence And Decreased Sex Drive

According to the drugs label, controlled studies in animals and humans didnt show that Zantac caused impotence or abnormal enlargement of the breasts called gynecomastia. But men taking the drug have reported cases of impotence and decreased sex drive when taken at high doses for a long period of time. These were comparable to the general population.

Both males and females have reported rare instances of gynecomastia and galactorrhea, a milky nipple discharge.

What Should I Know About Storage And Disposal Of This Medication

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture . Keep triazolam in a safe place so that no one else can take it accidentally or on purpose. Keep track of how many capsules are left so you will know if any are missing.

It is important to keep all medication out of sight and reach of children as many containers are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location รข one that is up and away and out of their sight and reach.

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website for more information if you do not have access to a take-back program.

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Triazolam May Cause Side Effects Tell Your Doctor If Any Of These Symptoms Are Severe Or Do Not Go Away:

  • drowsiness
  • swelling of the eyes, face, lips, tongue, or throat
  • feeling that the throat is closing
  • difficulty breathing or swallowing
  • hoarseness

Triazolam may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s MedWatch Adverse Event Reporting program online or by phone .

What Cancer Does Zantac Cause

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Research indicates that approximately 1.8 million people in the United States learn they have cancer in 2020. There are several reasons an individual may get cancer. Some people are genetically predisposed to certain types of cancer. Defects in a persons genes can lead to several types of cancer, including breast, kidney, prostate, and thyroid cancer. Other factors that can increase a persons risk of developing cancer include obesity, diet, smoking, and exposure to toxins and chemicals.

In some cases, individuals may develop cancer because they have been exposed to harmful toxins or chemicals. This exposure can come through contaminated ground or water. It can also stem from ingredients used in products. For example, exposure to lead paint has been linked to several types of cancer.

Individuals who took Zantac are also at risk of developing cancer. The types of cancers linked to Zantac and legal options for those who took this medication are explored here.

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