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Does Topamax Cause Insomnia

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Effects Of Tpm On Cognition In Patients With Psychiatric Disorders

Does anxiety cause insomnia?

While there is objective evidence that AEDs such as TPM negatively affect cognition in both bipolar and epilepsy patients , a past psychiatric history itself also predicts TPM-induced cognitive AEs . As TPM may play a valuable, second-line role in the treatment of psychiatric disorders, additional studies are warranted to assess for adverse cognitive events in psychiatric populations.

Aside from the bipolar spectrum disorders, there are few reports on incident cognitive AEs related to TPM use in other psychiatric conditions. One preliminary study of recently sober patients with alcoholism demonstrated positive cognitive effects of TPM . However, this study lacked a placebo group. Therefore, differentiation between positive effects of TPM versus alcohol discontinuation remains inconclusive. In post-traumatic stress disorder and borderline personality disorder, TPM was proposed to facilitate traumatic memory extinction. It is interesting to note that traumatic memory extinction is not thought to be due to the memory-impairing properties of TPM, since memory retrieval is necessary fear memory extinction .

More Research Is Needed

While there are numerous links between chronic migraine and sleep issues, the bigger issue is that we need more research into the relationship between the two ailments. My own experience with a neurologist and headache specialists alike has been their lack of interest in helping a patient deal with the insomnia aspect of their medical issues. Physicians all too frequently dismiss their patients\’ concerns of insomnia. If more doctors would take their patients insomnia seriously and work to help them resolve that issue, their overall migraine days and pain levels may be lowered by sleep alone.

Topamax To Treat Seizures

Topamax is FDA-approved to treat epilepsy in adults as well as children ages 2 years and older. Its used as initial monotherapy. This means its prescribed before any other medications are added. Topamax is used to treat:

  • Partial-onset seizures. For the purpose of treating partial-onset seizures, Topamax may be used alone or with other drugs to treat seizures. These are called antiepileptic drugs.
  • Generalized tonic-clonicseizures. For the purpose of treating generalized tonic-clonic seizures, Topamax may be used alone or with other antiepileptic drugs.
  • Seizures linked toLennox-Gastaut syndrome. For this purpose, Topamax is used with other antiepileptic drugs.

Topamax is taken to help prevent seizures. It is a type of drug called an anticonvulsant. Topamax is also called an antiepileptic drug.

Epilepsy is a condition that causes repeated seizures . The type of seizure you have depends on the part of your brain thats affected.

Partial-onset seizures

With partial-onset seizures, also called focal seizures, the excessive electrical activity starts in only one part of your brain. Partial seizures dont make you lose consciousness.

Partial seizures are referred to as simple or complex. With simple partial seizures, you may have muscle twitching in one part of your body or a change in your senses. This could be a tingling feeling or a change in taste, smell, or vision. You may have trouble communicating but still be aware of your surroundings.

Generalized tonic-clonic seizures

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How To Take Topamax

You should take Topamax according to your doctors or healthcare providers instructions.

Topamax comes in two different forms: a tablet that you swallow and a sprinkle capsule. The capsule can be swallowed whole or opened to sprinkle on a spoonful of soft food and swallowed.

If you have trouble swallowing Topamax tablets, talk with your doctor about using Topamax sprinkle capsules instead.

Dosage For Preventing Migraine Headaches

Can topamax cause liver damage . can topamax cause liver ...

Topamax is recommended for preventing migraine headaches* in adults and in children ages 12 years and older. The usual recommended dosage is 50 mg taken once in the morning and once in the evening.

Your doctor will gradually increase your dosage to this level over the first 4 weeks of treatment. This allows your body to get used to the medication and helps reduce the frequency and severity of side effects.

The dosage is usually increased as described below, but it may be raised more slowly if needed:

  • Week 1: 25 mg every evening
  • Week 2: 25 mg every morning and 25 mg every evening
  • Week 3: 25 mg every morning and 50 mg every evening
  • Week 4: 50 mg every morning and 50 mg every evening

* For details on the uses of Topamax, see the Topamax uses section above.

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Important Information About All Medicines

Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.

This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.

If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.

Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

If you have any questions about this medicine ask your pharmacist.

Is Topiramate Used For Anxiety


. Consequently, is topiramate a mood stabilizer?

Topiramate is most useful for people who have bipolar mood disorders that other mood stabilizers have been unable to control. It can relieve symptoms and make taking antidepressants possible for people who ere unable to take them before without experiencing mania or a mixed state.

how long does it take for Topamax to work? For epilepsy, it can take 1 to 2 weeks for topiramate to work properly. For migraines, it can take 1 month for migraine attacks to be less frequent. But it can take 2 to 3 months for topiramate to fully work.

Similarly, you may ask, can Topamax cause anxiety?

In a small number of people, Topamax has been known to cause suicidal thoughts or actions, new or worse anxiety, irritability, and depression as well as feelings of agitation, restlessness, aggression, panic attacks, mania, and insomnia. Don’t stop taking Topamax without talking to your doctor first.

What is topiramate used for?

Topiramate is used alone or with other medications to prevent and control seizures . This medication is also used to prevent migraine headaches and decrease how often you get them. Topiramate will not treat a migraine headache once it occurs.

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What Other Drugs Will Affect Phentermine And Topiramate

Phentermine and topiramate can cause irregular vaginal bleeding while you are taking birth control pills. This should not make the pills less effective in preventing pregnancy.

Using this medicine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your other medicines, especially:

  • acetazolamide
  • a diuretic or “water pill” or
  • insulin or oral diabetes medicine.

This list is not complete. Other drugs may affect phentermine and topiramate, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Topamax And Liver Health

How does insomnia affect a person’s health?

Topiramate is linked with hepatic failure.2 Kidney stone formation is another known outcome from taking Topamax.10 Where such risks to health are high, coming off the drug could be indicated despite the discomforts that can accompany medication withdrawal. Underlying conditions the drug suppresses, such as seizures or migraines can rebound during or after withdrawal, most notably where discontinuation is abrupt or sudden. Severe changes brought on by cessation can be avoided by a very gradual and well-monitored approach. Our general recommendations would minimally be two-fold:

  • Never abruptly discontinue anti-seizure medication .
  • Seek trained medical and clinical oversight during gradual tapering.
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    What Other Information Should I Know

    Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body’s response to phentermine and topiramate.

    Do not let anyone else take your medication. Giving or selling phentermine and topiramate to others may harm them and is against the law. Phentermine and topiramate is a controlled substance. Prescriptions may be refilled only a limited number of times ask your pharmacist if you have any questions.

    It is important for you to keep a written list of all of the prescription and nonprescription medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

    Topamax Side Effects List For Healthcare Professionals

    The following serious adverse reactions are discussed in more detail in other sections of the labeling:

    The data described in the following sections were obtained using Topamax Tablets.

    Clinical Trials Experience

    Because clinical trials are conducted under widely varying conditions, the incidence of adverse reactions observed in the clinical trials of a drug cannot be directly compared to the incidence of adverse reactions in the clinical trials of another drug, and may not reflect the incidence of adverse reactions observed in practice.

    Monotherapy Epilepsy

    Adults 16 Years of Age and Older

    The most common adverse reactions in the controlled clinical trial that occurred in adults in the 400 mg/day Topamax group and at an incidence higher than in the 50 mg/day group were: paresthesia, weight loss and anorexia .

    Approximately 21% of the 159 adult patients in the 400 mg/day group who received Topamax as monotherapy in the controlled clinical trial discontinued therapy due to adverse reactions. The most common adverse reactions causing discontinuation were difficulty with memory, fatigue, asthenia, insomnia, somnolence, and paresthesia.

    Pediatric Patients 6 to 15 Years of Age
    Body System

    Adjunctive Therapy Epilepsy

    Adults 16 Years of Age and Older
    Pediatric Patients 2 to 15 Years of Age



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    Sleep And Migraine Triggers

    Dr. Alex Nesbitt is a research fellow in Clinical Neurology in the Surrey Sleep Research Centre at the University of Surrey. He explains that while lack of sleep, too much sleep, shift-work, and jet lag are all known to be possible triggers for a migraine, excessive sleepiness can be an element of prodrome, and the actual sleep itself can help alleviate a migraine in some cases.1 I personally know many individuals that are episodic who can take a migraine abortive, go to sleep, and wake with the migraine completely gone. Some individuals can feel refreshed by nap, while others find they wake up with a headache or migraine.

    Topamax And Other Medications

    Does Phentermine Cause Insomnia

    Below are examples of medications that can interact with Topamax. This section doesnt contain all drugs that may interact with Topamax.

    Before taking Topamax, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

    If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

    Topamax and birth control

    Topamax can make birth control drugs that contain estrogen less effective at preventing pregnancy.

    Examples of birth control pills that can be made less effective by Topamax include:

    • levonorgestrel/ethinyl estradiol
    • desogestrel/ethinyl estradiol
    • drospirenone/ethinyl estradiol
    • norgestimate/ethinyl estradiol

    Topamax treatment can also make certain birth control medications less effective at preventing pregnancy. These include:

    If you use birth control that contains estrogen, your doctor may recommend switching to a different type of birth control medication while you take Topamax.

    Topamax and certain other seizure medications

    Taking Topamax with phenytoin or carbamazepine can lower the level of Topamax in your blood. This could make Topamax less effective at preventing seizures or migraine headaches.

    Topamax and Depakote

    • acetazolamide
    • zonisamide

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    Topamax And Metabolic Acidosis

    Topamax may cause an excessive amount of acid in the bloodstream, called metabolic acidosis. When this occurs, the body produces acid too quickly, and the kidneys cannot keep up with filtering it out. For this reason, patients with impaired kidney function or kidney disease should be monitored closely when taking Topamax.

    In extreme cases, metabolic acidosis can lead to kidney damage, shock, or even death. This condition can also cause soft or brittle bones and kidney stones, slow the growth rate in children, and harm a baby during pregnancy. Common metabolic acidosis symptoms include rapid breathing, low blood pressure, lethargy and confusion, and loss of appetite.

    What Happens With Epilepsy And Migraine

    Epilepsy and migraine are both neurological conditions. With epilepsy, you have seizures. With migraine, you have headaches, among other symptoms. But the conditions are considered to be linked, and many people have epilepsy and migraine together.

    The causes of epilepsy and migraine arent fully understood. But with both conditions, it seems that nerve cells in your brain are oversensitive to certain triggers, such as flickering lights or hormones.

    The trigger causes electrical signals to build up in the nerve cells in your brain. This causes them to fire inappropriate signals to other nerve cells. These nerve cells then pass on signals to other parts of your body. The increased electrical signaling can lead to a seizure in people with epilepsy. In people with migraine, it can lead to auras and headaches.

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    Pregnancy And Breastfeeding While Taking Topamax

    Below we provide information about Topamax and pregnancy and breastfeeding.

    Topamax and pregnancy

    It may not be safe to take Topamax while pregnant. If taken during pregnancy, the drug can cause side effects in children. These can include cleft palate and cleft lip, and being smaller than usual for their age.

    If youre pregnant or planning a pregnancy, talk with your doctor before starting Topamax. They may recommend a different drug for your condition.

    If you take Topamax during pregnancy, consider enrolling in the drugs pregnancy registry. Pregnancy registries collect information about the drugs effects when used during pregnancy. This helps researchers understand the risks of using Topamax during pregnancy, which can help others make decisions about their treatment.

    To enroll in the North American Antiepileptic Drug Pregnancy Registry, visit the registrys site. Or call 888-233-2334.

    Topamax and breastfeeding

    It may not be safe to use Topamax while breastfeeding. If taken while breastfeeding, Topamax may pass into breast milk. The drug may also cause a breastfed child to have diarrhea and sleepiness.

    Your doctor can talk with you about the risks and benefits of taking Topamax while breastfeeding.

    Does Topamax Cause Long

    Causes of Insomnia

    In most cases, side effects from Topamax are temporary. Most side effects tend to go away soon after you start or stop taking the drug.

    But severe side effects that could lead to long-term problems and permanent damage from Topamax are possible. For example, Topamax may cause eye side effects,* such as glaucoma. And if untreated, glaucoma could cause blindness.

    If you have questions about possible long-term side effects of Topamax, talk with your doctor or pharmacist.

    * To learn more about this side effect, see the Side effects explained section below.

    Below are answers to a few frequently asked questions about Topamaxs side effects.

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    How To Use Topamax

    Read the Medication Guide and, if available, the Patient Information Leaflet provided by your pharmacist before you start taking topiramate and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

    Take this medication by mouth with or without food as directed by your doctor, usually twice daily. To prevent kidney stones from forming, drink plenty of liquids while taking this medication unless your doctor instructs you otherwise.

    If you are using the tablet form of this medication, swallow the tablets whole since breaking them may leave a bitter taste.

    If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose.

    Dosage is based on your medical condition and response to treatment. For children, the dosage is also based on weight. Your doctor will gradually increase your dose to reduce your risk of side effects. For some conditions, you may start treatment with topiramate once daily at bedtime and slowly increase your dose to twice a day. It may take several weeks or months to reach the best dose for you and to get the full benefit from this medication.

    Tell your doctor if your condition persists or if it worsens.

    Is Topamax A Wonder Drug

    Over the past week alone, I have talked to several people about their doctor visits. Each one of them had a different illness and each one of them was prescribed the drug Topamax. I cannot help but wondering, how it is possible that one medication can treat so many disparate illnesses. I suspect it cannot and the overreach is driven more by marketing than medicine. This led me to do some digging into Topamax.

    What I found is not good. Topamax is prescribed for a broad scope of illnesses for which there is likely little evidence of its efficacy. Take a look at the list below.

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    Drug Forms And Strengths

    Topamax comes in two different forms:

    • A tablet that you swallow. Its available in strengths of 25 milligrams , 50 mg, 100 mg, and 200 mg.
    • A sprinkle capsule. The capsule can be swallowed whole or opened to sprinkle on a spoonful of soft food and swallowed. The capsule is available in strengths of 15 mg and 25 mg.

    If you have trouble swallowing Topamax tablets, talk with your doctor about using Topamax sprinkle capsules instead.

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