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Is Insomnia Genetic Or Environmental

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Can All Hereditary Sleep Disorders Be Cured

What is Insomnia?Causes, Signs and symptoms, Diagnosis and treatment

Genetic insomnia is often easier to cure than other hereditary conditions, because its influenced by external and environmental factors. Unfortunately, there are some parts of your genes you might not be able to overcome as easily.

Narcolepsy with cataplexy is one example of a sleeping disorder which may be influenced by genetics. There are medications available to assist with this condition, such as Sodium Oxybate, which helps to improve nighttime sleep and reduce daytime drowsiness. Unfortunately, theres no cure for this condition.

Another hereditary sleep disorder is familial advanced sleep phase syndrome, which is categorized by waking up too early, or sleeping for too long during the night.

There are some treatments available for this, like light therapy, which could be helpful for some patients.

Fatal familial insomnia is the most severe form of genetic insomnia, and it has no cure. Currently, experts predict this condition affects around 1 in 1 million people each year.

This genetic abnormality causes the death of neurons in the brain, and causes problems with the regulation of body temperature. Fatal familial insomnia occurs due to a mutation in the gene called PRNP, which harms the nervous system.

Over time, the condition causes increasingly worsening brain damage. Although this condition is very serious, its also very rare.

With a little luck, youll never have to deal with this condition, or encounter anyone else who has.

Can Genetic Insomnia Be Cured

So, can insomnia be cured?

This is a complicated question. Insomnia is an issue a lot of people face for different reasons. Ultimately, your body will eventually get some sleep, whether you like it or not.

However it can take some time and practice to find a cure to improve your sleep pattern.

The reality is insomnia is usually a symptom of another, underlying issue, rather than an independent problem on its own.

Insomnia is usually accompanied by things, like stress or anxiety, depression, discomfort, or even various other sleep disorders.

For instance, if you have restless leg syndrome, or talk in your sleep, youre more likely to have insomnia too.

Since insomnia isnt a standalone issue, fixing the problem often means finding the underlying cause.

Around 20% of the US population has an anxiety disorder, and insomnia is one of the most common symptoms caused by depression and anxiety.

If you have problems with your emotional or mental health, then getting to the bottom of those will often help with your insomnia too.

Depression and anxiety are also conditions with genetic links. If your family members have suffered with insomnia and anxiety, then you might experience both of these things too.

However, this will only be the case when youre exposed to the right environmental factors.

Biological And Clinical Insights From Genetics Of Insomnia Symptoms

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Try Cognitive Behavioral Therapy For Insomnia

Cognitive behavioral therapy for insomnia is considered the most effective treatment for insomnia. Over a course of several sessions, a therapist works with you to help you understand the thoughts and behaviors you have about sleep. Then, you learn to replace the unhealthy thoughts and behaviors with healthier ones using various techniques, such as:

  • Reframing the bed as a place for sleep. This may include making your bedroom environment more comfortable, refraining from using the bed for any other activity besides sleep and sex, and leaving the bedroom if you cant fall asleep within a short period of time.
  • Following a regular sleep-wake cycle. Specifically, people learn to set a consistent bedtime and wake time, and follow those every day of the week.
  • Identifying negative, stressful, or maladaptive thoughts that contribute to your insomnia. Once identified, you learn techniques to interrupt or talk back to those thoughts with healthier beliefs.
  • Practicing good sleep hygiene. Sleep hygiene includes behaviors that promote healthy sleep. A person with a genetic predisposition toward insomnia may want to be more diligent about following these practices.

Whether you are genetically predisposed to insomnia or not, you have the power to take action and improve your sleep. If your insomnia is not going away over time or your sleep troubles interfere with your quality of life, talk to your doctor. Your doctor can identify any underlying issues and suggest potential treatments.

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Insomnia: A combo of genetics and environment?  Genetic Lifehacks

Its not just mental disorders which can cause insomnia either. Genetic disorders often passed through families, like diabetes, can also influence your risk of having a sleep issue.

To cure genetic insomnia, your doctor will often talk to you to get to the bottom of the problem. Theres likely to be more to it than just bad sleep. Once you know what the issue is, you can begin a treatment strategy, which might combine:

  • Cognitive behavioral therapy and stress relief
  • Yoga, meditation, or breathing control
  • Sleep hygiene improvement
  • Medications for underlying illness

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Lifestyle And Environmental Insomnia Risk Factors

Work environment and stressful life events often have a distinct positive correlation with ones susceptibility for insomnia. Some major risk factors include having a high-stress job, experiencing distressful life events, and maintaining poor sleep hygiene. People who work night shifts or who work long and erratic hours are also at higher risk for insomnia.

Your sleeping environment or bed can also affect your ability to fall asleep and stay asleep. If your room is loud or very bright, it can heighten the risk of insomnia for you. Some useful tips to fall asleep include relaxing before bed, creating a calming sleep environment, and reducing screen time before bed.

Physical Psychiatric And Genetic Insomnia Risk Factors

Trouble sleeping can happen at any age for anyone, but there are certain characteristics, genetics, and lifestyles that put you at risk for developing insomnia.As you get older, you have an increased risk of developing insomnia. This is due in part to a general age-related decrease in the functioning of the body, and the increased likelihood of taking medications that interfere with sleep.2

Psychiatric illnesses, mood disorders, or other underlying medical conditions can further put one at risk for insomnia. Chronic anxiety and depression are two common conditions that can predispose someone to insomnia. This often leads people to ruminate on their thoughts before bed, and be unable to unwind and relax enough to sleep. In some cases, anxiety predisposes one to insomnia, and in some cases, insomnia can heighten the likelihood of anxiety. Having other medical conditions can also heighten the risk of insomnia, either as a side effect of the condition itself or due to medications used to treat it.

Some studies have shown that insomnia may be genetic, and if people in your family suffer from insomnia, you might be at higher risk for developing it. Women are also much more likely than men to develop insomnia. This is partially because women often experience sleep disturbances that occur with changing hormonal levels due to PMS, menopause, or pregnancy.3

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Genetic Evidence For Causal Association Between Asthma And Insomnia

To confirm the relation between insomnia and risk of asthma, we performed a logistic regression analysis using insomnia questionnaires. The analysis confirmed that insomnia had a positive association with asthma . Pair-wise analysis revealed that participants who answered sometimes showed 1.16 times higher OR than those who answered never/rarely. Further, the participants who answered usually showed 1.42 times higher OR than those who answered never/rarely .

You Can Inherit A Higher

Is Insomnia Genetic? True or False?

Understanding gene expression helps us to appreciate why the genes that you inherit from your parents predict your risk of developing insomnia, not whether you will absolutely develop it or not. Your sleeping habits are governed by your gene expression, not your genes themselves. You can influence which genes are expressed and which arent through habits and certain behaviors.That doesnt mean that someone with a genetic predisposition for insomnia wont suffer restless nights. If youre predisposed for insomnia, you need to be more careful around bedtime. Looking at your phone or watching TV before bed may seem inconsequential for some people, but for you, those behaviors may trigger the genes that keep you up at night.

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Sleep Is An Important Part Of Your Health

Aside from your genes, many behaviors and lifestyle choices will influence how well you sleep. As mentioned earlier, we can help by providing a specific treatment plan to help you manage your sleep issues. If you feel like youve tried everything, and youre still struggling to sleep at night, please contact us. We can work with you to determine the underlying cause of your insomnia and come up with a customized plan to address your needs.

Despite any questions you may be asking yourself about whether your issues with insomnia have a genetic component, the path to properly address your insomnia is the same. Our team has the expertise to address your issues with insomnia and help you get the sleep you deserve. and discover how we can help.

Polygenic Risk For Insomnia In Adolescents Of Diverse Ancestry

  • 1Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI, United States
  • 2Department of Biostatistics, College of Public Health and Health Professionals and College of Medicine, University of Florida, Gainesville, FL, United States
  • 3Biostatistics and Computational Biology, National Institute of Environmental Health Sciences, Durham, NC, United States

Background: Insomnia is a common mental disorder, affecting nearly one fifth of the pre-adult population in the United States. The recent, largest genome-wide association study conducted on the United Kingdom Biobank cohort identified hundreds of significant single-nucleotide polymorphism , allowing the epidemiologists to quantify individual genetic predisposition in the subsequent studies via the polygenic risk scoring technique. The nucleotide polymorphisms and risk scoring, while being able to generalize to other adult populations of European origin, are not yet tested on pediatric and adolescent populations of diverse racial-ethnic backgrounds, and our study intends to fill these gaps.

Materials and Methods: We took the summary of the same United Kingdom Biobank study and conducted a polygenic risk score analysis on a multi-ethnicity, pre-adult population provided by the Adolescent Brain Cognitive Development Study.

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What Sleep Disorders Are Genetic

Scientists have focused on families and the connection with sleep disorders, even focusing on twins with similar sleep problems. It is believed that environment, physical condition, and genetics all play a part in a variety of sleep disorders, including snoring and sleep apnea. Recent research has gone as far as finding gene mutations in family members that share a particular sleep disorder.Most causes of sleep disorders are environmental, however, several have a strong genetic link, including:

  • Insomnia

Large Study Confirms That Insomnia Is Hereditary

Sleep Deprivation and Depression
Researchers have identified specific genes that may trigger the development of sleep problems, and have also demonstrated a genetic link between insomnia and psychiatric disorders such as depression, or physical conditions such as type 2 diabetes.

Researchers have identified specific genes that may trigger the development of sleep problems, and have also demonstrated a genetic link between insomnia and psychiatric disorders such as depression, or physical conditions such as type 2 diabetes. The study in the journal Molecular Psychiatry, which is published by Springer Nature, was led by Murray Stein of the University of California San Diego and the VA San Diego Healthcare System.

Up to 20 percent of Americans and up to 50 percent of US military veterans are said to have trouble sleeping. The effects insomnia has on a person’s health can be debilitating and place a strain on the healthcare system. Chronic insomnia goes hand in hand with various long-term health issues such as heart disease and type 2 diabetes, as well as mental illness such as post-traumatic stress disorder and suicide.

“A better understanding of the molecular bases for insomnia will be critical for the development of new treatments,” he adds.

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Classification Of Participants On The Basis Of Their Insomnia Symptoms

To classify participants based on their insomnia symptoms, the following question was asked: Do you have trouble falling asleep at night or do you wake up in the middle of the night?. The participants were able to choose one of the following four answers: never/rarely, sometimes, usually, or prefer not to answer. This data was used to classify the participants insomnia states, and those who answered prefer not to answer were excluded. Consequently, we transformed these categorical variables into quantitative variables as follows: 0=never/rarely, 1=sometimes, and 2=usually for further analysis.

More Evidence To Suggest That Your Insomnia Is Genetic

In 2016, a study on mice found that certain sleep traits, like insomnia, have genetic underpinnings. Several studies of human twins have also suggested that insomnia can be an inherited trait. Now, new research published in Molecular Psychiatry not only reinforces that finding, but also suggests that there may be a genetic link between insomnia and some other psychiatric and physical disorders, like depression and type 2 diabetes, as Psych Central alerts us.

Insomnia is particularly prevalent in populations of military veterans. For this study, researchers at VA San Diego Healthcare System analyzed questionnaire responses and blood samples from almost 33,000 new soldiers at the beginning of basic training, along with pre- and post-deployment surveys from nearly 8000 soldiers deployed to Afghanistan starting in early 2012. They conducted genome-wide association tests to determine the heritability of insomnia and links between insomnia and other disorders. The results were adjusted for the presence of major depression .

The genotype data showed that insomnia disorder was highly heritable and pinpointed potential genes that may be involved. The study indicated that there’s a strong genetic correlation between insomnia and major depression. They also found a significant genetic correlation between insomnia and type 2 diabetes.

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Understanding Your Sleep Genes

Genetic insomnia is a real thing, but your parents having insomnia isnt a guarantee youll also suffer. There are various genes in your body that can influence parts of your life.

Your gene expression is what dictates whether youll really notice the impact of those genes or not. If youre concerned about your sleep genes, you could consider looking into genetic testing.

Many of the genetic testing kits on the market today can test for the genes that make you more predisposed to insomnia.

However, you may find it more helpful to speak to people in your family who have already experienced this problem. Find out how theyve handled their sleep issues over the years, and try improving your own sleep hygiene.

If youre concerned about your sleep problems, then you should also book an appointment with a doctor. Remember, insomnia is just a symptom of an underlying problem most of the time.

Speaking to your doctor will make it easier for you to come up with a treatment strategy that addresses the root of the issue, so you can enjoy a better quality of sleep.

Siestio. Sleep matters.

General advice disclaimerThis article contains general tips and advice. However, no diet or exercise program should be started without consulting your physician or other industry professional first. For more information read our full disclaimer here.

Multivariate Model Of First And Insomnia

A Zebrafish Genetic Screen Identifies Nmu as a Sleep Regulator

The results presented in the previous section establish that both sleep reactivity to stress, as measured with the FIRST, and insomnia have significant genetic and nonshared environmental influences. In this section we examine to what extent these influences overlap with a bivariate genetic Cholesky decomposition model30: In this model, the A and E estimates for the FIRST also predict insomnia, and insomnia also has its own A and E influences . This model, which fits the data well, 2 = 41.65, P = 0.655 CFI = 1.00 RMSEA = 0.000, is shown in Figure 2 . As shown by the cross path estimated for A1 to Insomnia, the genetic influences on FIRST also significantly influenced insomnia, and to a similar extent in males and females . As indicated by the path from A2 to insomnia, insomnia also had genetic influences that were independent of FIRST, though these influences were only marginally significant for males, 2diff = 3.05, P = 0.081. The path from E1 to insomnia indicates that the environmental influences on FIRST scores also influenced insomnia, to a higher extent in males than females . The path from E2 to insomnia indicates that insomnia had nonshared environmental influences that were independent of those for FIRST.

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How Bad Can Genetic Insomnia Be

Studies show a few sleep disorders have an established basis in our genes. The genetic makeup passed throughout families can influence the way the brain responds to sleep triggers.

You may also be genetically predisposed to getting a lower quality of sleep, with fewer deep sleep or REM periods.

According to one piece of in-depth research, there are around 57 regions of the genome can be linked to symptoms of insomnia.

There are various forms of hereditary insomnia, some more worrisome than others. Some of the most common hereditary sleep disorders linked to the genes include:

  • Chronic primary insomnia
  • Familial advanced sleep-phase syndrome
  • Fatal familial insomnia
  • Narcolepsy with cataplexy

Perhaps the most dangerous form of hereditary insomnia is fatal familial insomnia. This is an extremely rare condition that causes difficulty sleeping and potential brain damage.

An inability to sleep gradually destroys various parts of the brain in this condition, causing premature death.

Fortunately, not all forms of genetic insomnia are deadly.

It is possible to overcome various forms of insomnia, including those caused by genes.

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